Tfeb and liver

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August undefined, 2024

Web21 Apr 2013 · The observation that TFEB gain and loss of function in the liver influences whole body energy metabolism suggests that TFEB stimulates the liver secretion of factors that affect the function of other tissues. This is likely to be mediated by PGC1α and PPARα, which are known to regulate the production of secreted hormones 37–39. Web10 Feb 2024 · Protein levels of JMJD3, TFEB, ATG7, ULK1, LC3-II, and p-ERK, detected by IB of liver extracts (Fig. 9b) or IHC of liver sections (Fig. 9c), were decreased in the patients.

Homocysteine accelerates hepatocyte autophagy by upregulation of TFEB …

Web17 Feb 2024 · For example, TFEB activates autophagy to indirectly inhibit liver steatosis and against weight gain in obesity (Zhang Y. et al., 2024). TFEB also contributes to being a … WebDynamic MTORC1-TFEB feedback signaling regulates hepatic autophagy, steatosis and liver injury in long-term nutrient oversupply Normal metabolism requires a controlled balance … crossword kidnapped monogram

Role of TFEB in Autophagy and the Pathogenesis of Liver …

Web1 day ago · The steatosis of liver cells was evaluated with Oil red O (ORO) fat staining, and the TFEB expression in liver tissues of rats in each group was tested by immunohistochemistry (IHC). The immunofluorescence technique (IFT) was used to test LC3, p62, and TFEB expression in liver tissues, and Western blotting (WB) was used to … Web1 day ago · The steatosis of liver cells was evaluated with Oil red O (ORO) fat staining, and the TFEB expression in liver tissues of rats in each group was tested by … Web6 May 2024 · The role of TFEB in alcohol-associated liver injury. Roles for TFEB-mediated autophagy have also been shown in other types of liver injury. Deficiency of alpha-1 … crossword kids of boomers

TFEB; Beyond Its Role as an Autophagy and Lysosomes Regulator

Web5 Sep 2024 · Trehalose, a disaccharide, activates TFEB and protects against diet-induced nonalcoholic fatty liver disease in mice. The aim of the present study was to investigate whether trehalose would reverse the impairment of TFEB induced by alcohol and protect against alcohol-induced liver injury. Methods Web21 Apr 2013 · Tcfeb expression was significantly induced in liver, muscle and kidney of mice subjected to 24 h of food deprivation ( Fig. 1a ). Similar results were observed in vivo … builders finance fundWeb31 Mar 2024 · Results: Liver tissues from mice on the ethanol diet had lower levels of total and nuclear TFEB, compared with control mice, and hepatocytes had reduced lysosome biogenesis and autophagy. crossword kigali\u0027s country

"Web23 Jun 2024 · Originally described as an oncogene, TFEB is now widely known as a regulator of various processes, such as energy homeostasis, stress response, metabolism, and autophagy-lysosomal biogenesis... " - Tfeb and liver

Tfeb and liver

Impaired TFEB-mediated Lysosome Biogenesis and Autophagy …

Web7 Apr 2024 · 溶酶体功能抑制剂或干扰tfeb表达显著抑制槲皮素对乙醇所致细胞损伤的保护作用。综上所述，槲皮素协同激活自噬，通过恢复溶酶体功能减少外泌体释放，并进一步减轻乙醇诱导的肝损伤。 Web21 Apr 2013 · Tcfeb expression was significantly induced in liver, muscle and kidney of mice subjected to 24 h of food deprivation ( Fig. 1a ). Similar results were observed in vivo using a heterozygous...

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Web5 Sep 2024 · Trehalose, a disaccharide, activates TFEB and protects against diet-induced nonalcoholic fatty liver disease in mice. The aim of the present study was to investigate … Web6 May 2024 · Owing to its ability to improve disease status in murine models, TFEB has attracted attention as a therapeutic target for diseases. In this review, we will present the …

Web15 May 2024 · This study was conducted to investigate the autophagic response of Sertoli cells (SCs) to acute ethanol toxicity using in vivo and in vitro models. Adult Wistar rats were intraperitoneally injected with either 5 g/kg ethanol or phosphate-buffered saline (for the control group) and sacrificed 0, 3, 6 and 24 h after injection. Compared to the control … Web18 May 2024 · Transcription Factor EB (TFEB), a master regulator of lysosomal biogenesis and autophagy, is known to be involved in osteoblast and myeloid differentiation, but its role in lineage commitment in...

Web2 days ago · When nutrients are replete, TFEB is phosphorylated by MTORC1, then interacts with YWHA/14-3-3 and remains in the cytosol, whereas starvation leads to the inactivation of MTORC1 and a rapid ... Web7 Oct 2024 · As a protein that is capable of being imported or exported to the nucleus, TFEB possesses a nuclear localization signal (NLS) identified between amino acids 241 and 252, while the nuclear export signal (NES) is located at …

Web28 Oct 2024 · In this aggressive liver disease setting, loss of Flcn led to activation of transcription factors TFEB and TFE3 to promote autophagy, promoting the degradation of intracellular lipid stores ...

Web12 Apr 2024 · 世界卫生组织（WHO）研究数据显示超过40%的肝脏疾病跟酒精滥用相关【1】。酒精性肝病（alcohol-associated liver disease, ALD）是由于长期过量饮酒导致的肝脏一系列慢性病变过程。ALD初期通常表现为酒精性脂肪肝，进而发展为以肝脏 ... crossword kids printableWeb23 Jul 2024 · Transcription factor EB (TFEB) is a master transcriptional regulator of lysosomal biogenesis and autophagy and, when activated, is effective against disorders of lipid metabolism. However, the role of TFEB in hepatic steatosis is not well understood. crossword kids clubWeb6 May 2024 · A gene network regulated by TFEB has been studied using microarray, chromatin immunoprecipitation sequencing (ChIP-seq), and RNA sequencing in cell lines … builders finance incWeb2 days ago · When nutrients are replete, TFEB is phosphorylated by MTORC1, then interacts with YWHA/14-3-3 and remains in the cytosol, whereas starvation leads to the inactivation … crossword kilimanjaro is its highest pointWeb6 May 2024 · TFEB in controlling liver cell fate during development and regeneration, which may also . contribute to the development of biliary cancer [80]. It als o sugge sted tha t the ex pressio n . builders finance indepence moWeb14 Sep 2024 · Transcription factor EB (TFEB) is involved in the pathogenesis of non-alcoholic fatty liver disease (NAFLD), and fibroblast growth factor 21 (FGF21) exerts a … builders fife scotlandWeb28 Apr 2024 · When cells are starving or mitochondria are damaged, TFEB located on the lysosome membrane can be activated for dephosphorylation in the nucleus, helping to regulate innate and adaptive immunity, cell metabolism, cell differentiation, and other important life processes. builders finance llc