Phenytoin pubmed

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August undefined, 2024

WebApr 12, 2024 · Antikonvulsiva haben vielfältigen Einfluss auf den Metabolismus von Sexualhormonen. So konnte unter einer Therapie mit enzyminduzierenden Antiepileptika (EIA) wie Phenytoin, Phenobarbital und Carbamazepin ein Anstieg von SHBG (Sex-Hormon-Bindungs-Globulin)-Konzentrationen bei Frauen und Männern mit Epilepsie beobachtet … WebNov 1, 2012 · Though the interaction between enteral tube feeding and phenytoin was first described 30 years ago, the mechanism of the interaction is still poorly understood. 1 One theory is that the drug can adhere to the plastic tubing when phenytoin is given via tube. 2 Another possibility is that physical incompatibility with the enteral nutrition causes …

Phenytoin Article - StatPearls

WebJan 15, 2024 · Phenytoin is a Vaughn Williams Class IB antiarrhythmic; although, it is almost never used as an antiarrhythmic anymore. Its effects on the cardiac voltage-gated sodium channels can lead to dysrhythmias as well as SA and AV nodal blocks although such effects have rarely been reported following ingestion of the oral form. WebPhenytoin C15H12N2O2 CID 1775 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity … the deanery school sutton coldfield

Phenytoin in traumatic brain injury Archives of Disease in Childhood

WebMay 1, 2016 · The original clinical trials and case reports listed in PUBMED in English language between the years of 1946-2014 were evaluated. As the key words, "phenytoin, diphenylhydantoin, epilepsy,... WebNov 28, 2024 · Phenytoin was measured in breastmilk in 5 women. In one taking 100 mg daily, a breastmilk levels of 0.76 mg/L was found 3 days postpartum. In 4 others taking 300 mg daily, milk levels on several occasions mostly during the first week postpartum ranged from 0.41 to 1.3 mg/L. Most of the levels were in the range of 0.5 to 0.6 mg/L. [10,11] WebJul 17, 2024 · Phenytoin, as the prototype for all anticonvulsants, was already positioned as an analgesic compound 70 years ago. Since these initial findings, the data that have been gathered have supported the use of anticonvulsants as painkillers – from phenytoin up to and including more recent anticonvulsants such as gabapentin and pregabalin. the deanery synergy login

Phenytoin - an overview ScienceDirect Topics

(PDF) Cardiovascular adverse effects of phenytoin - ResearchGate

WebJan 14, 2024 · Phenytoin is insoluble in water and is dissolved in a basic solution including ethylene glycol, the mixture being linked to tissue necrosis (“purple hand syndrome”) if extravasated [ 9 ]. Fosphenytoin, the prodrug of phenytoin, is water soluble and hence free of the toxic emulsion. the deanery primary school sutton coldfieldWebIt has been suggested that topical (applied directly to the skin) phenytoin may help in the healing of pressure ulcers, as it has been used topically to heal and reduce pain and swelling (inflammation) in a range of wounds, including those resulting from traumatic injury, other types of ulcers, and burns. the deanery c of e school

"WebAug 1, 2003 · Phenytoin (Dilantin) is one of the most effective drugs for treating acute seizures and status epilepticus. In addition, it is effective in the management of chronic epilepsy, particularly in... " - Phenytoin pubmed

Phenytoin pubmed

Epilepsy in glioma patients: mechanisms, management, and …

WebPharmacodynamics. Phenytoin is an anticonvulsant with a narrow therapeutic index. 5 Although the recommended therapeutic range is cited to be between 10-20 mg/L, differences in albumin levels, genetics, comorbidities, and body composition can make achieving an ideal phenytoin dose challenging. 5 For example, studies have confirmed … WebJan 15, 2024 · Phenytoin has a narrow therapeutic window, between 10-20 mg/L. Serum concentrations of phenytoin are monitored by measuring the total phenytoin …

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WebMay 17, 2013 · Phenytoin has been shown to induce hyperglycemia and hyperinsulinemia (12–15). Cyclophosphamide has been reported to cause elevated blood glucose levels during chemotherapy (16,17). These reports suggest that PXR might be involved in the drug-induced metabolic disorders. Recent studies have indeed linked PXR to lipid and glucose … WebJul 11, 2024 · Phenytoin is a medication used in the management and treatment of epilepsy, generalized tonic-clonic seizures, complex partial seizures, and status epilepticus. It is in …

WebSep 1, 2013 · Therapeutic drug monitoring of phenytoin is carried out to ensure effective and safe levels. Some of the factors complicating phenytoin dosing include a narrow therapeutic window, high degree of protein binding, and nonlinear pharmacokinetics. WebApr 19, 1975 · Phenytoin / therapeutic use Prednisolone / therapeutic use Urea / adverse effects Urea / analogs & derivatives* Substances Anticonvulsants Phenylbutyrates Phenytoin Urea ...

WebPhenytoin overdose has been described (101 A).. A 32-year-old man developed ataxia and nystagmus 1 hour after taking about 175 tablets of phenytoin 100 mg.He was given oral … WebNov 2, 2015 · A 1983 clinical trial randomly assigned 281 patients undergoing supratentorial craniotomy to phenytoin or placebo. 74 The most common indications for surgery included head injury (57%), aneurysm (20%), intra-axial tumor (16%), and meningioma (7%). No statistical significance in rates of seizures was observed between patients in the …

WebChronic oral administration of phenobarbital (PB) and phentyoin was studied in chronically implanted cats. The effects of two dosages (PB, 3 mg/kg and 15 mg/kg; phenytoin, 5 mg/kg and 8 mg/kg) were analyzed with two physiological measures: somatosensory evoked potentials (SEPs) and power spectral analysis of the EEG.

WebToxicokinetics. Phenytoin is slowly but nearly completely absorbed in the small intestine; oral bioavailability ranges from 70 to 100%. The drug is widely distributed in the body and … the deanery swindon sn1 7daWebTake this medication by mouth as directed by your doctor, usually 2 or 3 times a day. This product is not recommended for use once a day. You may take it with food if stomach … the deanery hereford cathedralWebDiscussion. Gingival hyperplasia is seen with many anticonvulsants, calcium channel blockers, and calcineurin inhibitors. Among anticonvulsants, this is seen most commonly with phenytoin, and phenobarbitone, primidone, valproate, carbamazepine, and vigabatrin being the other implicated drugs.[] Gingival hyperplasia usually develops after a period of … the deanery southwark cathedralWebSep 1, 2008 · Phenobarbital is an enzyme-inducing antiepileptic drug that interacts with oral contraceptives, causing decreased sex hormone levels 1 and breakthrough bleeding. 2 Midcycle breakthrough bleeding... the deanery wichelstoweWebIn the first seven days after serious head injury, phenytoin does prevent seizures in some patients (NNT = 10) but has not been shown to decrease mortality or post-traumatic epilepsy. For high risk patients, a physician must weigh the potential risks and benefits before making a decision. the deangelis groupWebPhenytoin is a long-standing, anti-seizure drug widely used in clinical practice. It has also been evaluated in the context of many other illnesses in addition to its original epilepsy … the deangelo companyWebPhenytoin has a narrow therapeutic index and the relationship between dose and plasma-drug concentration is non-linear; small dosage increases in some patients may produce large increases in plasma-drug concentration with acute toxic side-effects. the deanery house and garden