Dynein intermediate chain binding
WebFeb 6, 2024 · Previous studies have revealed that all tested cargo adaptors bind two subunits of dynein: the light-intermediate chain and the heavy chain [8. Lee I.-G. et al. ... which they designated the ‘heavy chain-binding site 1’ (HBS1) motif. Interestingly, both BICDR1 molecules in the structure use the HBS1 motif to interact with different dynein-A ... WebDynein axonemal heavy chain 5 is a protein that in humans is encoded by the DNAH5 gene. [5] [6] [7] DNAH5 is a protein-coding gene. 1 It provides the instructions for synthesizing a protein that belongs to a microtubule-associated protein complex made of heavy, light and intermediate chains. 2 DNAH5 is responsible for making the heavy …
Dynein intermediate chain binding
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WebCytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein … Web13411 Ensembl ENSG00000105877 ENSMUSG00000018581 UniProt Q96DT5 n/a RefSeq (mRNA) NM_001277115 NM_010060 RefSeq (protein) NP_001264044 n/a Location (UCSC) Chr 7: 21.54 – 21.9 Mb Chr 12: 117.84 – 118.16 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Dynein axonemal heavy chain 11 (DNAH11), is a …
WebJan 7, 2024 · Schroeder CM, Ostrem J, Hertz NT, Vale RD. A Ras-like domain in the light intermediate chain bridges the dynein motor to a cargo-binding region. eLife. 2014; 3:e03351. pmid:25272277 ... Mische S, He … WebHomodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition.
WebSep 7, 2024 · The Hook3 HBS1 region was predicted by running Colabfold 1.2.0 (no templates) on two copies of Hook3 172–287 , one copy of dynein heavy chain 576–864 … WebFeb 5, 2024 · Predicted to enable dynein intermediate chain binding activity and dynein light intermediate chain binding activity. Predicted to be involved in cilium assembly. Located in 9+0 non-motile cilium and centrosome. Is active in glutamatergic synapse and postsynapse. [provided by Alliance of Genome Resources, Apr 2024]
WebAuthor(s): Rahman, Farhana; Johnson, Jennifer L; Zhang, Jinzhong; He, Jing; Pestonjamasp, Kersi; Cherqui, Stephanie; Catz, Sergio D Abstract: The dynein motor protein complex is required for retrograde transport but the functions of the intermediate-light chains that form the cargo-binding complex are not elucidated and the importance …
WebJan 4, 2005 · Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. longshoreman warehouse unionWebEnter the email address you signed up with and we'll email you a reset link. hope lutheran church in enumclaw washingtonWebMay 15, 2015 · The intermediate chains (DYNC1I) play a key scaffold role in the dynein complex. In neurons, dynein complexes with different intermediate chain isoforms have … longshoreman washington stateEach molecule of the dynein motor is a complex protein assembly composed of many smaller polypeptide subunits. Cytoplasmic and axonemal dynein contain some of the same components, but they also contain some unique subunits. Cytoplasmic dynein, which has a molecular mass of about 1.5 megadaltons (MDa), is a dimer of dimers, containing approximately twelve polypeptide sub… hope lutheran church indian river miWebMar 7, 2024 · Dynein is a 1.4 MDa homodimeric complex of two heavy chains, which each binds smaller subunits, including the intermediate … longshoreman vancouver wa jobsWebThe dynein light intermediate chain . 2. The dynein accessory proteins Lis1, Nde and Ndel-1 . This will be achieved by studying and manipulating dynein and accessory protein activity using in vitro motility assays and living tissue culture cells. Importantly, we will also investigate the role of longshoreman west coastWebJul 13, 2001 · Insights into cytoplasmic dynein regulation have the potential to clarify the interactions necessary for cargo binding. In this study we explored the role of IC phosphorylation in regulating the IC-p150 Glued interaction. We mapped the site of IC phosphorylation, generated site-directed mutants, and tested the impact of these … longshoreman union saint john nb