WebFeb 28, 2024 · CTGF is a matricellular protein, involved in stabilization of transient fibrosis triggered by TGF-β1 activity, Citation 17, Citation 18 implying that AuNPs were able to destabilize collagen I through the inhibition of CTGF expression. In addition, the expressions of CTGF and TGF-β1 were decreased by AuNPs in colorectal cancer. WebAug 6, 2024 · Connective tissue growth factor (CTGF) is a member of the CCN matricellular protein family, consisting of four domains, that regulates the signaling of other growth factors and promotes kidney fibrosis. ... Exposure of mesangial cell to recombinant human CTGF significantly increased production of fibronectin and collagen type I. …
REDUCED EXPRESSION OF CONNECTIVE TISSUE GROWTH FACTOR (CTGF…
WebJul 1, 2007 · Connective tissue growth factor (CCN2) is a profibrotic factor acting downstream and independently of TGF-β to mediate renal fibrosis. Although … WebNov 19, 2024 · Increased collagen deposition in zona glomerulosa and zona fasciculata of E and RC was observed. Insular and irregular overexpression of CTGF was noted. The overall picture of CTGF expression matched the Masson’s trichrome. No significant difference was observed in Ki-67 expression. Conclusions: The results of the current … chukar recipes slow cooker
CTGF is a central mediator of tissue remodeling and fibrosis and …
WebConnective tissue growth factor is a growth factor with similar activities on collagen metabolism as TGF-β. It is a cysteine-rich peptide produced by fibroblasts and … WebFinally, silica exposure could further increase the expression levels of key molecules in the Rac1/MLK3/JNK/AP-1 cascade reaction regulated by CTGF and ultimately up-regulate the expression level of collagen I. Considering the important role of CTGF and collagen I in the process of pulmonary fibrosis [32], combined with the above results, we ... Knockout mice with the Ctgf gene disrupted die at birth due to respiratory stress as a result of severe chondrodysplasia. Ctgf-null mice also show defects in angiogenesis, with impaired interaction between endothelial cells and pericytes and collagen IV deficiency in the endothelial basement membrane. CTGF is also important for pancreatic beta cell development, and is critical for normal ovarian follicle development and ovulation. destiny mat type