Cisplatin binding
WebJan 18, 2024 · Once inside cells, cisplatin undergoes aquation, and the platinum atom of cisplatin binds covalently to the N 7 position of purines resulting in about 65% GpG, … WebSep 1, 2024 · Cisplatin dose not undergo the instantaneously and reversible binding to plasma protein that is characteristic of normal drug-protein binding. Platinum from …
Cisplatin binding
Did you know?
WebThe binding affinity of ligands in this study was evaluated on the basis of E-value (kcal/mol), number of hydrogen bonds, pi-pi bonds and other hydrophobic interactions against selected targets that are reported to be involved in development of resistance of cancer cells against cisplatin (Figure 6; Table 3). WebMay 26, 2024 · Using the fluorescent cisplatin analog BODIPY-cisplatin, two-dimensional gel electrophoresis, and mass spectrometry, we identified the protein binding partners in …
WebCisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. Therefore, identifying novel biomarkers to improve the diagnosis and treatment of NSCLC is important. WebSep 3, 2024 · Cisplatin is widely used for the treatment of various solid tumors. It is mainly administered by intravenous injection, and a substantial amount of the drug will bind to …
WebJul 24, 2024 · The aim of this work is to identify the cisplatin binding sites on human H-chain ferritin. High-resolution X-ray crystallography reveals that cisplatin binds four distinct protein sites, that is, the side chains of His136 and Lys68, the side chain of His105, the side chain of Cys90 and the side chain of Cys102. WebSep 27, 2024 · Nausea and Vomiting: cisplatin for injection can cause severe nausea and vomiting. Use highly effective antiemetic premedication [see Dosage and Administration ( 2.1) and Warnings and Precautions ( 5.3 )]. • Myelosuppression: cisplatin for injection can cause severe myelosuppression with fatalities due to infections.
WebAug 19, 2005 · Binding of cisplatin to proteins reduces urinary excretion of platinum, and causes deposition of platinum in tissues. Binding of cisplatin to proteins and enzymes is generally believed to be the cause of several severe side effects exhibited by these drugs, especially ototoxicity and nephrotoxicity.
WebJun 2, 2016 · Cisplatin is a widely prescribed anticancer drug, which triggers cell death by covalent binding to a broad range of biological molecules. Among cisplatin targets, … cindy sukhooWebCisplatin crosslinks DNA by binding adjacent guanine bases on a strand. These crosslinks kink the DNA, hampering its normal function and damaging the cell and its genome. … cindy suhWebUV/Vis spectroscopy confirms the stoichiometry of binding and shows that cisplatin and iron(III) binding are competitive. The binding of cisplatin has been modelled by using … cindy suireWebCisplatin binds to two adjacent guanines, called crosslinking, at the N7 position. [1] Cisplatin’s ability to bind to adjacent guanines arises from its cis structure, as the cis chlorines can be exchanged for water molecules … diabetic friendly berry crispcindy sullivan obituaryWebcells. Non-DNA binding drugs, such as vinca alkaloids, do not attach to DNA within the surrounding tissue.1 Subsequently, indirect damage occurs immediately in the tissue outside the vein. Because these drugs do not bind to the DNA, these agents are metabolized in the tissue and are easily neutralized as compared with DNA-binding agents.17 cindy sughrueWebThe combination of adenoviruses and chemotherapy agents is a novel approach for human cancer therapeutics. A meticulous analysis between adenovirus and chemotherapeutic agents can help to design an effective anticancer therapy. Human antigen R (HuR) is an RNA binding protein that binds to the AU-rich element (ARE) of specific mRNA and is … cindy summerfield